董琳(川大教授)

时间:2023-12-06 21:24:15编辑:小周

董琳(川大教授)的个人简介

董琳,女,四川人,博士,四川大学华西药学院教授,博士生导师。

人物经历

1994-1998郑州大学化学系,化学专业,理学学士

2001-2006中国科学院成都有机化学研究所,有机化学专业,硕博连读,师从龚流柱教授

2006-2009 澳大利亚昆士兰大学化学系,博士后,师从Craig M. Williams教授

2009-2011 新加坡科技研究局化学与工程科学研究院,研究科学家,师从著名化学家K. C. Nicolaou 教授

2011-2016四川大学华西药学院,副教授

2016-至今四川大学华西药学院,教授

获奖情况

1、2012年 四川大学优秀青年骨干教师奖励

2、2014年 大学生课外科技实践活动优秀指导教师

3、2016年 四川大学唐立新优秀学者奖

研究方向

1、有机合成方法学研究

2、天然产物与药物合成

科研项目

1、2013-2015国家自然科学基金-青年基金

2、2016-2019 国家自然科学基金-面上项目

发表论文

[1] Liu, C.-F.; Zhang, G.-T.; Sun, J.-S.;Dong, L.*, “Access to π-conjugated azaindole derivatives via rhodium(III)-catalyzed cascade reaction of azaindoles and diazo compounds”,Org. Biomol. Chem.2017,15, 2902u20132905.

[2] Xia, Y.-Q.;Dong, L.*, “Ruthenium(II)-Catalyzed Indolo[2,1-a]isoquinolines Synthesis by Tandem C?H Allylation and Oxidative Cyclization of 2-Phenylindoles with Allyl Carbonates”,Org. Lett.,2017,19, 2258?2261.

[3] Zhang, G.-T.;Dong, L.*, “Synthesis of Polycyclic Amides via Tandem RhIII-Catalyzed C-H

Activation and Annulation from Dioxazolones and Alkynes”,Asia. J. Org. Chem.2017,6, 812 u2013 816.

[4] Wu, L.;Dong, L.*, “The application of Morita-Baylis-Hillman reaction: Synthetic studies on perophoramidine”,Tetrahedron2017, 73,3966-3972.

[5] Li, S.-S.; Liu, C.-F.; Zhang, G.-T.; Xia, Y.-Q.; Li, W.-H.;Dong, L.*, “A Convenient One-Pot Route to Screw-Shaped [5]Azahelicenes via Rhodium(III)-Catalyzed Multiple C-H Bond Activation”,Chem. Asia. J.2017,12, 415-418.

[6] Li, S.-S.; Xia, Y.-Q.; Liu, C.-F.; Zhang, G.-T.; Su, F.; Zhang, X.-M.;Dong, L.*, “Diverse Reactivity in a Rhodium(III)-Catalyzed Vinylic sp2 Cu2013H Bond Functionalization: Synthesis of Fused Polycyclic Heteroarenes or Conjugated Dienes”,Adv. Synth. Catal.2016,358(23), 3724 u20133729.

[7] Lin, H.;Dong, L.*, “One-Pot Synthesis of Decahydropyrene via Tandem C?H Activation/Intramolecular Diels?Alder/1,3-Dipolar Cycloaddition”;Org. Lett.,2016,18, 5524?5527.

[8] Li, S.-S.; Xia, Y.-Q.; Hu, F.-Z.; Liu, C.-F.; Su, F.;Dong, L.*, “Ir-Catalyzed One-Pot Cascade ynthesis of Pentacyclic-Fused Carbazoles from Indoles and Diazoes”,Chem. Asia. J.2016,11,3165 u2013 3168.

[9] Li, W.-H.; Wu, L.; Li, S.-S.; Liu, C.-F.; Zhang, G.-T.;Dong, L.*, “Rhodium-Catalyzed Hydrogen-Releasing ortho-Alkenylation of 7-Azaindoles”,Chem. Eur. J.2016,22(50), 17926u2013 17929.

[10] Zhu, Y.-Q.; Qin, L.; Song, Q.; Su, F.; Xu, Y.-J.;Dong, L.*, “Rhodium(III)-catalyzed ortho-alkenylation using a cyclic N-phosphoryl ketimine as the directing group”,Org. Biomol. Chem.2016,14, 9472u20139475.

[11] Li, S.-S.; Wu, L.; Qin, L.; Zhu, Y.-Q.;Su, F.; Xu, Y.-J.;Dong, L.*, “Iridium(III)-Catalyzed Tandem [3 + 2] Annulation: Synthesis of Spirocyclic Phosphoramide Derivatives”,Org. Lett.,2016,18(17), 4214u20134217.

[12] Li, S.-S.; Li, W.-H.; Zhang, G.-T.; Xia, Y.-Q.; Liu, C.-F.; Su, F.; Zhang, X.-M.;Dong, L.*, “One-pot construction of fused polycyclic heteroarenes involving 7-azaindoles and α,β-unsaturated ketones”,Org. Biomol. Chem.,2016, 14,7859u20137863.

[13] Wang, C.-Q.; Zhang, W., Lin, H.; Su, F.;Dong, L.*, “Synthesis of Isoquinolinium Salts via Rh(III)-catalyzed Oxidative Annulation between Aldehyde Imines and Alkynes”,HETEROCYCLES,2016, 92(9),1674-1686.

[14] Li, S.-S.; Lin, H.; Liu, C.-F.; Xia, Y.-Q.; Zhang, X.-M.;Dong, L.*, “Rhodium-Catalyzed Tandem Annulation Reactions of 7-Azaindoles with Electron-Deficient Olefins via Double C-H Activation”,Adv. Synth. Catal.2016, 358,1595 u20131601.

[15] Li, S.-S.; Liu, C.-F.; Xia, Y.-Q.; Li, W.-H.; Zhang, G.-T.; Zhang, X.-M.;Dong, L.*, “A unique annulation of 7-azaindoles with alkenyl esters to produce π-conjugated 7-azaindole derivatives”,Org. Biomol. Chem.,2016, 14,5214u20135218.

[16] Li, S.-S.; Qin, L.;Dong, L.*, “Rhodium-catalyzed Cu2013C coupling reactions via double Cu2013H activation”,Org. Biomol. Chem.,2016,14,4554-4570.

[17] Li, S.-S.; Wang, C.-Q.; Li, W.-H.; Zhang, X.-M.;Dong, L.*, “Rhodium-catalyzed selective oxidative coupling of 7-azaindoles”,Tetrahedron2016, 72,2581-2586.

[18] Zhang, W., Wang, C.-Q.; Lin, H.;Dong, L.*, Xu, Y.-J, “Synthesis of Mesoionic Isoquinolines by Rhodium(III)-Catalyzed C-H Activation”,Chem. Eur. J.2016, 22,907-910.

[19] Li, S.-S.; Wang, C.-Q.; Lin, H.; Zhang, X.-M.;Dong, L.*, “Rhodium(III)-catalyzed Cu2013C coupling of 7-azaindoles with vinyl acetates and allyl acetates”,Org. Biomol. Chem.,2016,14, 229u2013237.

[20] Zhu, Y.-Q.;Dong, L.*, “One-Pot Synthesis of Polysubstituted Spirofluorene?Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel?Crafts Cyclization”,J. Org. Chem.2015,80 (20), 9973?9979

[21] Lin, H.; Li, S.-S.;Dong, L.*, “Synthesis of indoles and polycyclic amides via ruthenium(II)-catalyzed C-H activation and annulation”,Org. Biomol. Chem.2015,13, 11228-11234

[22] Li, S.-S.; Wang, C.-Q.; Lin, H.; Zhang, X.-M.;Dong, L.*, “Rhodium(III)-Catalyzed Oxidative Annulation of 7u2011Azaindoles and Alkynes via Double C?H Activation”Org. Lett.2015,17, 3018-3021.

[23] Huang, J.-R.; Qin, L.; Zhu, Y.-Q.; Song, Q.;Dong, L.*“Multi-site Cyclization via Initial C-H Activation Using Rhodium(III) Catalyst: Rapid Assembly of Frameworks Containing Indoles and Indolins”Chem. Comm.2015,51, 2844-2847.

[24] Li, S.-S.; Lin, H.; Zhang, X.-M.;Dong, L.* “Ruthenium-Catalyzed Direct C3 Alkylation of Indoles with α,β-Unsaturated Ketones”,Org. Biomol. Chem.2015,13,1254-1263.

[25] Zhang, W.; Zhang, Q.-R.;Dong, L.* “Rhodium-catalyzed [2+2+2] cycloaddition reactions of terminal alkynes with N-sulfonyl ketimines”,Tetrahedron Letters2015,56, 546u2013548.

[26] Zhang, Q.-R.; Huang, J.-R.; Zhang, W.;Dong, L.* “Highly Functionalized Pyridines Synthesis fromN-Sulfonyl Ketimines and Alkynes Using N-S Bond as an Internal Oxidant”,Org. Lett.2014,16, 1684-1687.

[27] Huang, J.-R.; Song, Q.; Zhu, Y.-Q.; Qin, L.; Qian, Z.-Y.;Dong, L.* “Rhodium(III)-Catalyzed Three-Component Reactions of Imines, Alkynes, and Aldehydes via Cu2013H Activation”,Chem. Eur. J.2014,20, 16882-16886.

[28]Dong, L.*; Qu, C.-H.; Huang, J.-R.; Zhang, W.; Zhang, Q.-R.; Deng, J.-G. “Rhodium-catalyzed Spirocyclic Sultam Synthesis by [3+2] Annulation with CyclicN-Sulfonyl Ketimines and Alkynes”,Chem. Eur. J.2013,19, 16537-16540.

[29]Dong, L.*; Huang, J.-R.; Qu, C.-H.; Zhang, Q.-R.; Zhang, W.; Han, B.; Peng, C.* “Rhodium(III)-catalyzed vinylic sp2 Cu2013H bond functionalization: efficient synthesis of pyrido[1,2-α]-benzimidazoles and imidazo[1,2-α]pyridines”,Org. Biomol. Chem.2013,11, 6142u20136149.

[30] Huang, J.-R.; Zhang, Q.-R.; Qu, C.-H.; Sun, X.-H.;Dong, L.* Chen. Y.-C.* “Rhodium(III)-Catalyzed Direct Selective C(5)-H Oxidative Annulations of 2-Substituted Imidazoles and Alkynes by Double C-H Activation”,Org. Lett.2013,15, 1878-1881.

[31] Huang, J.-R.;Dong, L.*; Han, B.; Peng, C.; Chen. Y.-C. “Synthesis of Aza-Fused Polycyclic Quinolines via Double C-H Bond Activations”,Chem. Eur. J.2012,18, 8896-8898.

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