崔京南

时间:2023-12-11 17:45:43编辑:小周

崔京南的个人简介

崔京南,男,毕业于日本冈山大学,是大连理工大学博士生导师。

人物经历

1978-1982年:毕业于东北电力学院、电厂化学专业,学士学位;

1992-1995年:毕业于日本冈山大学、应用化学专业,硕士学位;

1995-1998年:毕业于日本冈山大学、合成有机化学专业,博士学位;

1999-2006年:大连理工大学、精细化工国家重点实验室,副教授;

2006-2007年:瑞典皇家工学院,化学系,访问学者;

2007年--至今:大连理工大学、精细化工国家重点实验室,教授,博士生导师

研究方向

荧光分析技术在食品安全和环境污染中微量有害物质快速检测方法研究荧光探针设计、合成及生物酶活性检测

社会兼职

(1)J. Org. Chem.; (2)Tetrahedron Lett.; (3)Bioorg. Med. Chem.; (4)Int. J. Mol. Sci. 等学术期刊审稿人。

著作论文

[1]Feng, Lei,Ma, Xiaochi,Tian, Xiangge,Yu, Zhenlong,Zhao, Xinyu,Sun, Chengpeng,Cui, Jingnan,Ning, Jing,Wang, Chao,Zhang, Baojing.A two-photon ratiometric fluorescent probe for imaging and quantitative analysis of botanic glucosyltransferase: A key enzyme for the biosynthesis of bioactive glycosides[J],SENSORS AND ACTUATORS B-CHEMICAL,2019,282:112-121

[2]Ning, Jing,Huo, Xiaokui,Feng, Lei,Wang, Chao,Sun, Chengpeng,Cui, Jingnan,James, Tony D.,Ma, Xiaochi,Liu, Tao,Dong, Peipei,Wang, Wei,Ge, Guangbo,Wang, Bo,Yu, Zhenlong,Shi, Lei,Tian, Xiangge.Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2019,141(2):1126-1134

[3]Tian, Xiangge,Zhou, Dayong,Wang, Chao,Sun, Chengpeng,Ning, Jing,Ma, Xiaochi,Tian, Zhenhao,Wang, Yan,Hou, Jie,Feng, Lei,Song, Liang,Cui, Jingnan,Huo, Xiaokui,Zhao, Xinyu.A highly selective fluorescent probe for detecting glutathione transferases to reveal anticancer-activity sensitivity of cisplatin in cancer cells and tumor tissues[J],SENSORS AND ACTUATORS B-CHEMICAL,2018,277:423-430

[4]Feng, Lei,Ning, Jing,Ma, Xiao-Chi,Li, Ping,Hou, Jie,Cui, Yong-Lei,Tian, Xiang-Ge,Yu, Zhen-Long,Cui, Jing-Nan,Wang, Chao,Huo, Xiao-Kui.Identification and Isolation of Glucosytransferases (GT) Expressed Fungi Using a Two-Photon Ratiometric Fluorescent Probe Activated by GT[J],ANALYTICAL CHEMISTRY,2018,90(22):13341-13347

[5]Jiao, Long,Song, Fengling,Cui, Jingnan,Peng, Xiaojun.A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy[J],CHEMICAL COMMUNICATIONS,2018,54(66):9198-9201

[6]Liu, Tao,Wang, Chao,Cui, Jing-Nan,Yan, Qu-Long,Feng, Lei,Ma, Xiao-Chi,Tian, Xiang-Ge,Yu, Zhen-Long,Ning, Jing,Huo, Xiao-Kui,Sun, Cheng-Peng.Isolation of gamma-Glutamyl-Transferase Rich-Bacteria from Mouse Gut by a Near-Infrared Fluorescent Probe with Large Stokes Shift[J],ANALYTICAL CHEMISTRY,2018,90(16):9921-9928

[7]Huo, Xiaokui,Ma, Xiaochi,Tian, Xiangge,Li, Yannan,Feng, Lei,Cui, Yonglei,Wang, Chao,Cui, Jingnan,Sun, Chengpeng,Liu, Kexin.highly selective ratiometric fluorescent probe for real-time imaging of beta-glucuronidase in living cells and zebrafish[J],SENSORS AND ACTUATORS B-CHEMICAL,2018,262:508-515

[8]Li, Pengbo,Wang, Yiru,Zhang, Shufang,Xu, Liang,Wang, Gongchen,Cui, Jingnan.An ultrasensitive rapid-response fluorescent probe for highly selective detection of HSA[J],TETRAHEDRON LETTERS,2018,59(14):1390-1393

[9]Liu, Tao,Zhao, Xinyu,Huo, Xiaokui,Sun, Chengpeng,Cui, Jingnan,Feng, Lei,Ma, Xiaochi,Ning, Jing,Wang, Bo,Dong, Bin,Li, Song,Tian, Xiangge,Yu, Zhenlong,Peng, Yulin,Wang, Chao.Activatable Near-Infrared Fluorescent Probe for Dipeptidyl Peptidase IV and Its Bioimaging Applications in Living Cells and Animals[J],ANALYTICAL CHEMISTRY,2018,90(6):3965-3973

[10]Jin, Yinzhu,Wang, Chao,Ning, Jing,Zhang, Baojing,Feng, Lei,Ma, Xiaochi,Tian, Xiangge,Jin, Lingling,Cui, Yonglei,Liu, Tao,Yu, Zhenlong,Huo, Xiaokui,Cui, Jingnan,Sun, Chengpeng.Highly Specific near-Infrared Fluorescent Probe for the Real-Time Detection of beta-Glucuronidase in Various Living Cells and Animals[J],ANALYTICAL CHEMISTRY,2018,90(5):3276-3283

[11]Zhang Chuanmin,Zhang Shubiao,Zhi Defu,Cui Jingnan.Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems.[J],Current medicinal chemistry,2018,25(28):3319-3332

[12]焦龙,宋锋玲,崔京南,彭孝军.A near infrared heptamethine aminocyanine dye with a long-living excited triplet state for photodynamic therapy[J],Chemical Communications, 2018, 54, 9198 u2013 9201.,2018,54:9198-9201

[13]Lv, Xia,Yang, Ling,Feng, Lei,Ai, Chun-Zhi,Hou, Jie,Wang, Ping,Zou, Li-Wei,Cheng, Jie,Ge, Guang-Bo,Cui, Jing-Nan.A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin[J],JOURNAL OF MEDICINAL CHEMISTRY,2017,60(23):9664-9675

[14]Qiao, Qinglong,Liu, Wenjuan,Chen, Jie,Zhou, Wei,Yin, Wenting,Miao, Lu,Cui, Jingnan,Xu, Zhaochao.A naphthalimide-derived fluorogenic probe for SNAP-tag with a fast record labeling rate[J],DYES AND PIGMENTS,2017,147:327-333

[15]Ge, Guang-Bo,Yang, Ling,Feng, Lei,Jin, Qiang,Wang, Yi-Ru,Liu, Zhao-Ming,Zhu, Xin-Yue,Wang, Ping,Hou, Jie,Cui, Jing-Nan.A novel substrate-inspired fluorescent probe to monitor native albumin in human plasma and living cells[J],ANALYTICA CHIMICA ACTA,2017,989:71-79

[16]Jin, Qiang,Yang, Ling,Feng, Lei,Zhang, Shui-Jun,Wang, Dan-Dan,Wang, Fang-Jun,Zhang, Yi,Cui, Jing-Nan,Guo, Wen-Zhi,Ge, Guang-Bo.Real-Time Tracking the Synthesis and Degradation of Albumin in Complex Biological Systems with a near-Infrared Fluorescent Probe[J],ANALYTICAL CHEMISTRY,2017,89(18):9884-9891

[17]Jiao, Long,Song, Fengling,Zhang, Biyou,Ning, Houfu,Cui, Jingnan,Peng, Xiaojun.Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods[J],JOURNAL OF MATERIALS CHEMISTRY B,2017,5(26):5278-5283

[18]Wang, Yi-Ru,Feng, Lei,Xu, Liang,Hou, Jie,Jin, Qiang,Zhou, Nan,Lin, Yuan,Cui, Jing-Nan,Ge, Guang-Bo.An ultrasensitive and conformation sensitive fluorescent probe for sensing human albumin in complex biological samples[J],SENSORS AND ACTUATORS B-CHEMICAL,2017,245:923-931

[19]Dai, Ziru,Ge, Guang-Bo,Yang, Ling,Feng, Lei,Cui, Jing-Nan,Jin, Qiang.A HIGHLY SELECTIVE RATIOMETRIC TWO-PHOTON FLUORESCENT PROBE FOR HUMAN CYTOCHROME P450 1A1 AND ITS APPLICATION[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S37-S37

[20]Jin, Qiang,Feng, Lei,Wang, Dandan,Ge, Guang-Bo,Cui, Jing-Nan,Ling, Yang.A HIGHLY SELECTIVE NEAR-INFRARED FLUORESCENT PROBE FOR CARBOXYLESTERASE 2 AND ITS BIOIMAGING APPLICATIONS IN LIVING SYSTEMS[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S22-S22

[21]Lv, Xia,Feng, Lei,Cui, Jing-Nan,Yang, Ling,Ge, Guang-Bo.A TURN ON FLUORESCENT PROBE FOR HUMAN UDP-GLUCURONOSYL TRANSFERASE 1A1 AND BILIRUBIN METABOLISM EVALUATION[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S35-S35

[22]宋锋玲,崔京南,彭孝军.Improving brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods[J],Journal of Materials Chemistry B,2017,5:5278-5283

[23]Dai, Zi-Ru,Yang, Ling,Feng, Lei,Jin, Qiang,Cheng, Hailing,Li, Yan,Ning, Jing,Yu, Yang,Ge, Guang-Bo,Cui, Jing-Nan.A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study[J],CHEMICAL SCIENCE,2017,8(4):2795-2803

[24]丁乐乐,田镇豪,侯洁,翁仔淼,崔京南,杨凌,葛广波.基于BODIPY母核的羧酸酯酶1特异性荧光探针底物的设计研发[J],药学学报,2017,52(1):58-65

[25]Jin, Qiang,Cui, Jing-Nan,Yang, Ling,Feng, Lei,Wang, Dan-Dan,Wu, Jing-Jing,Hou, Jie,Dai, Zi-Ru,Sun, Shi-Guo,Wang, Jia-Yue,Ge, Guang-Bo.A highly selective near-infrared fluorescent probe for carboxylesterase 2 and its bioimaging applications in living cells and animals[J],BIOSENSORS & BIOELECTRONICS,2016,83:193-199

[26]Cui, Jing-Nan,Xu, Liang.A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants[J],CHEMICAL COMMUNICATIONS,2016,52(36):6064-6067

[27]Cui, Jing-Nan.A highly selective marker reaction for measuring the activity of human carboxylesterase 1 in complex biological samples[J],RSC ADVANCES,2016,6(6):4302-4309

[28]Cui, Jing-Nan.A Two-Photon Ratiometric Fluorescent Probe for Imaging Carboxylesterase 2 in Living Cells and Tissues[J],ACS APPLIED MATERIALS & INTERFACES,2015,7(51):28474-28481

[29]Cui, Jing-Nan.A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(45):14488-14495

[30]Cui, Jing-Nan.An optimized ratiometric fluorescent probe for sensing human UDP-glucuronosyltransferase 1A1 and its biological applications[J],BIOSENSORS & BIOELECTRONICS,2015,72:261-267

[31]Cui, Jing-Nan.A highly selective fluorescent ESIPT probe for the detection of Human carboxylesterase 2 and its biological applications[J],BIOSENSORS & BIOELECTRONICS,2015,65:9-15

[32]Cui, Jingnan.Coumarin 545: an emission reference dye with a record-low temperature coefficient for ratiometric fluorescence based temperature measurements[J],ANALYST,2015,140(4):1008-1013

[33]Cui, Jing-Nan.A ratiometric fluorescent sensor for highly selective detection of human carboxylesterase 2 and its application in living cells[J],SENSORS AND ACTUATORS B-CHEMICAL,2014,205:151-157

[34]Feng, Lei,Liu, Zhao-Ming,Xu, Liang,Lv, Xia,Ning, Jing,Hou, Jie,Ge, Guang-Bo,Cui, Jing-Nan,Yang, Ling.A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications[J],CHEMICAL COMMUNICATIONS,2014,50(93):14519-14522

[35]Cui, Jingnan.A fluorescent probe based on N-butylbenzene-1,2-diamine for Cu(II) and its imaging in living cells[J],JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY,2014,80(3-4):383-390

[36]Liu, Zhao-Ming,Feng, Lei,Ge, Guang-Bo,Lv, Xia,Hou, Jie,Cao, Yun-Feng,Cui, Jing-Nan,Yang, Ling.A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase 1[J],BIOSENSORS & BIOELECTRONICS,2014,57:30-35

[37]Liu, Tianyu,Liu, Xiaogang,Spring, David R.,Qian, Xuhong,Cui, Jingnan,Xu, Zhaochao.Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe[J],SCIENTIFIC REPORTS,2014,4:5418

[38]崔京南.A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase1[J],Biosensors & Bioelectronics,2014,57(1):30-35

[39]崔京南.A highly selective long-wavelength fluorescent probe for human carboxylesterase 2 and its biomedical applications[J],Chem. Commun,2014,50(50):14519-14522

[40]崔京南.Quantitatively Mapping Cellular Viscosity with Detailed OrganelleInformation via a Designed PET Fluorescent Probe[J],SCIENTIFIC REPORTS,2014,4(5418):1-7

[41]Zou, Chunyan,Qiao, Qinglong,Zhao, Miao,Mao, Deqi,Wang, Danfeng,Feng, Lei,Cui, Jingnan,Xu, Zhaochao.A ratiometric fluorescent probe for fluoride ion based on naphthoimidazolium receptor[J],RSC ADVANCES,2014,4(82):43746-43751

[42]Qiao, Qinglong,Zhao, Miao,Lang, Haijing,Mao, Deqi,Cui, Jingnan,Xu, Zhaochao.A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J],RSC ADVANCES,2014,4(49):25790-25794

[43]Song, Xinwei,Liu, Fengyu,Sun, Shiguo,Wang, Jingyun,Cui, Jingnan,Peng, Xiaojun.An NIR dye encapsulated by a supramolecular assembly for imaging mitochondria in living cells with ultrastable photostability[J],RSC ADVANCES,2014,4(18):9326-9329

[44]Liu, Tianyu,Zhang, Xinfu,Qiao, Qinglong,Zou, Chunyan,Feng, Lei,Cui, Jingnan,Xu, Zhaochao.A two-photon fluorescent probe for imaging hydrogen sulfide in living cells[J],DYES AND PIGMENTS,2013,99(3):537-542

[45]Song, Xinwei,Liu, Fengyu,Sun, Shiguo,Cui, Jingnan,Fan, Jiangli,Song, Fengling,Peng, Xiaojun.O-atom effect on the dynamic balance between redox-induced viologen derivative radical and its dimer modulated by cucurbit[8]uril[J],SUPRAMOLECULAR CHEMISTRY,2013,25(7):401-408

[46]Chen, Tao,Zheng, Yi,Xu, Zhaochao,Zhao, Miao,Xu, Yongnan,Cui, Jingnan.A red emission fluorescent probe for hydrogen sulfide and its application in living cells imaging[J],TETRAHEDRON LETTERS,2013,54(23):2980-2982

[47]Wu, Zhiyong,Cui, Jingnan,Qian, Xuhong.Rational design of fluorescent viscosity sensors by the principle of photoinduced electron transfer[J],TETRAHEDRON LETTERS,2013,54(21):2575-2578

[48]Liu, Tianyu,Xu, Zhaochao,Spring, David R.,Cui, Jingnan.A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells[J],ORGANIC LETTERS,2013,15(9):2310-2313

[49]Wu, Zhi-Yong,Cui, Jing-Nan,Qian, Xu-Hong,Liu, Tian-Yu.A 4-aminonaphthalimide based environmentally sensitive fluorescence probe[J],CHINESE CHEMICAL LETTERS,2013,24(5):359-361

[50]王专,崔京南,欧其,吴祖望.三苯二嗪型蓝色活性染料研究进展[J],染料与染色,2013,50(1):10-13

[51]Wang, Min,Xu, Zhaochao,Wang, Xu,Cui, Jingnan.A fluorescent and colorimetric chemosensor for nitric oxide based on 1,8-naphthalimide[J],DYES AND PIGMENTS,2013,96(2):333-337

[52]王专,崔京南,欧其,吴祖望.三苯二f嗪型蓝色活性染料研究进展[A],第十二届全国染料与染色学术研讨会暨信息发布会,2012,16-20

[53]王静,程耀邦,边悦玲,徐兆超,崔京南.苯萘体系普朔尔环化反应中桥原子与取代基对芳香自由基诱导分子内1,5-氢转移的影响[J],中国科技论文,2012,6:454-461

[54]Xing, Junling,Cui, Jingnan,Wang, Shuang,Gao, Jin,Zhang, Zhichao.Novel acenaphthopyrazine derivatives as antitumor agents against MCF-7 cells: molecular synthesis, optical properties, and DNA-binding studies[J],MONATSHEFTE FUR CHEMIE,2012,143(2):243-250

[55]Chen, Xiufu,Wang, Jingyun,Cui, Jingnan,Xu, Zhaochao,Peng, Xiaojun.A ratiometric and exclusively selective Cu-II fluorescent probe based on internal charge transfer (ICT)[J],TETRAHEDRON,2011,67(26):4869-4873

[56]Miao, Qingqing,Wu, Liqiong,Cui, Jingnan,Huang, Mingdong,Ma, Tingli.A New Type of Dye-Sensitized Solar Cell with a Multilayered Photoanode Prepared by a Film-Transfer Technique[J],ADVANCED MATERIALS,2011,23(24):2764-2768

[57]杨翠翠,孔志霞,崔京南.用于染料敏化太阳能电池的苊并吡嗪类染料的合成[J],精细化工,2011,28(7):633-638

[58]Xie, Lijuan,Cui, Jingnan,Qian, Xuhong,Xu, Yufang,Liu, Jianwen,Xu, Ruian.5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior[J],BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(2):961-967

[59]崔京南.Design and synthesis of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells[J],Jingxi Huagong (2011), 28(7), 633-638,2011,28(7):633-638

[60]Wang Xing-yong,Cui Jing-nan,Ren Wei-min,Zhao Guo-quan,Li Feng,Qian Xu-hong.Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes[J],CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2010,26(6):981-985

[61]Wang, Kewei,Qian, Xuhong,Cui, Jingnan.Design, synthesis, and bioactivity of cyanonitrovinyl neonicotinoids as potential insecticides[J],MONATSHEFTE FUR CHEMIE,2010,141(10):1117-1122

[62]Kong, Zhixia,Zhou, Huizhi,Cui, Jingnan,Ma, Tingli,Yang, Xichuan,Sun, Licheng.A new class of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells[J],JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2010,213(2-3):152-157

[63]Li, Xiaolian,Wang, Qianqian,Qing, Yang,Lin, Yanjie,Zhang, Yingli,Qian, Xuhong,Cui, Jingnan.Novel DNA intercalators without basic side chains as efficient antitumor agents: Design, synthesis and evaluation of benzo-[c,d]-indol-malononitrile derivatives[J],BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(9):3279-3284

[64]Wang, Lixiao,Wang, Xingyong,Cui, Jingnan,Ren, Weimin,Meng, Nan,Wang, Jingyun,Qian, Xuhong.Preparation of chiral trans-5-substituted-acenaphthene-1,2-diols by baker’s yeast-mediated reduction of 5-substituted-acenaphthylene-1,2-diones[J],TETRAHEDRON-ASYMMETRY,2010,21(7):825-830

[65]Xu, Zhaochao,Pan, Jie,Spring, David R.,Cui, Jingnan,Yoon, Juyoung.Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach[J],TETRAHEDRON,2010,66(9):1678-1683

[66]Xu, Zhaochao,Baek, Kyung-Hwa,Kim, Ha Na,Cui, Jingnan,Qian, Xuhong,Spring, David R.,Shin, Injae,Yoon, Juyoung.Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2010,132(2):601-610

[67]崔京南.Design, Synthesis and Bioactivity of Vinylnitro-cyano Neonicotinoids as Potential Insecticides[J],Monatsh. Chem.,2010,141:1117-1120

[68]吴志勇,崔京南.Polarity Sensors Based on Photoinduced Electron Transfer Mechamism[A],The 2nd Workshop on Fluorescence Chemsensors and Bio-imagings,2010,88-89

[69]Wang, Kewei,Qian, Xuhong,Cui, Jingnan.One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds[J],TETRAHEDRON,2009,65(50):10377-10382

[70]Xie, Lijuan,Xiao, Yi,Wang, Fang,Xu, Yufang,Qian, Xuhong,Zhang, Rong,Cui, Jingnan,Liu, Jianwen.Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation[J],BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(21):7615-7621

[71]Xie, Lijuan,Xu, Yufang,Wang, Fang,Liu, Jianwen,Qian, Xuhong,Cui, Jingnan.Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies[J],BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(2):804-810

[72]崔京南.Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: synthesis, cytotoxicity, DNA-binding and cell cycle evaluation[A],Bioorg. Med. Chem,2009,17(21):7615-7621

[73]Wang, Kewei,Cui, Jingnan,Xie, Lijuan,Qian, Xuhong.Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides[J],HETEROATOM CHEMISTRY,2009,20(7):418-424

[74]Tong, Lian Peng,Cui, Jing Nan,Ren, Wei Min,Wang, Xing Yong,Qian, Xu Hong.Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones[J],CHINESE CHEMICAL LETTERS,2008,19(10):1179-1182

[75]Xie, Lijuan,Qian, Xuhong,Cui, Jingnan,Xiao, Yi,Wang, Kewei,Wu, Peichun,Cong, Liying.Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies[J],BIOORGANIC & MEDICINAL CHEMISTRY,2008,16(18):8713-8718

[76]佟连鹏,张建伟,孔志霞,崔京南.一种具有变色效应的可在生理pH下检测Co~(2+)的荧光探针[A],中国化学会第26届学术年会光化学分会场,2008,1

[77]孔志霞,王兴涌,张建伟,崔京南.利用动物肝脏质粒还原芳香硝基类化合物[A],中国化学会第26届学术年会有机化学分会场,2008,1

[78]Li, Gangyue,Qian, Xuhong,Yan, Shenggang,Cui, Jingnan,Zhang, Rong,Xiao, Yi.Synthesis, herbicidal activity, and structure-bioactivity relationship of pyridyl-containing 2-phenyliminothiazolidines[J],MONATSHEFTE FUR CHEMIE,2008,139(2):169-178

[79]崔京南.一种具有变色效应的可在生理pH下检测Co2+的荧光探针[A],中国化学会第二十六届学术年会,2008

[80]边悦玲,崔京南,程耀邦,徐兆超.以氮为桥原子的芳香自由基诱导的1,5-芳香氢转移的研究[A],中国化学会第二十五届学术年会,2006,1

[81]卢春亮,崔京南,徐兆超.一种在生理pH下比例荧光检测Cd_(2+)的水溶性化学传感器[A],中国化学会第二十五届学术年会,2006,1

[82]王兴涌,崔京南,李峰,任伟民.生物转化法制备手性5-溴-1,2-二羟基苊[A],中国化学会第二十五届学术年会,2006,1

[83]崔京南,程耀邦,徐兆超,张大奎.芳香自由基诱导的芳香氢转移:供吸电子取代基的影响[A],中国化学会第四届有机化学学术会议,2005,Vol.25:1

[84]崔京南,李峰,任伟民,乔卉莹.利用生物转化制备芳香羟胺:反应体系的pH、温度和时间对反应选择性的影响[A],中国化工学会;北京化工大学,2005

[85]张勉,崔京南.1,8-萘酐类水溶性荧光染料的合成[J],精细化工,2004,21(10):782-784

[86]Qian X.,Cui J.,Zhang R..Intramolecular aromatic 1,5-hydrogen transfer in preparation of oxacyclic naphthalic anhydride via unusual Pschorr cyclisation[J],Chemical Communications,2001,24:2656-2657

主要成就

相关研究成果在J. Am. Chem. Soc.; Org. Lett.; Chem. Commun; J. Org.Chem.; Sci. Rep; Biosensors and Bioelectronics等杂志发表论文50余篇,共被引用700余次;获得国家专利授权20余项;作为项目负责人获得资助国家自然科学基金面上项目3项、国家科技支撑计划、国家自然科学基金重大培育计划、上海市科委科研项目各1项。

1、通过把荧光检测技术引入食品安全领域,将传统快速检测仪器的定性检测提高至定量检测,特别是将重金属离子检测限由10 mg/L降低至0.05 mg/L;已完成便携式食品安全荧光快速检测仪开发;

2、完成数码彩色打印专用染料及墨水制备工艺开发,产品打破国外产品垄断,大幅降低价格,使国外产品基本退出国内市场;成果获得国家科技发明二等奖(大幅面数码喷墨染料及其应用,2006年,第二位获奖人)。

3、开发金属离子、中性小分子、阴离子、粘度、生物酶(乙酰胆碱酶、羧酸酯酶、人血清蛋白酶和P450酶)等高选择性、比例检测的双通道荧光探针30余种;成果获得上海市自然科学一等奖(生物功能色素及荧光分子传感器,2008年,第三位获奖人)。

奖励:

(1)国家技术发明二等奖,2006年,大幅面数码喷墨染料及其应用,彭孝军、崔京南、张 蓉、王力成、樊江丽、王力军;

(2)上海市自然科学一等奖,2008年,生物功能色素及荧光分子传感器,钱旭红、肖 义、崔京南、徐玉芳;

专利

一种用于识别硫化氢的特异性荧光探针及其应用

一种苯并噻唑类识别硫化氢的荧光探针及其应用

一种用于识别半胱氨酸的特异性荧光探针及其应用

一种以苊并吡嗪为母体的高灵敏性荧光探针、制备及应用

芳杂环基咪唑并萘酰亚胺类化合物及其应用

一类苊并吡嗪染料及其在染料敏化太阳能电池上的应用

一类邻二氰基苊并吡嗪化合物及其抗肿瘤应用

手性2-羟基苊酮类化合物的制备方法

一种萘酰亚胺荧光染料及其制备和应用

一种染料型中性墨水及其制备方法

科研项目

当前位置: 崔京南 科学研究 科研项目

人源羧酸酯酶1亚型选择性荧光探针设计、合成与生物学应用, 国家自然科学基金, 2015/08/18, 进行

制笔行业关键材料及制备技术研发与产业化, 国家科技支撑计划项目, 2011/06/01, 完成

基于刚性、稠环芳香醇的手性分子荧光探针设计与合成,高等学校博士学科点专项科研基金项目, 2010/12/02, 完成

利用生物转化法制备刚性、稠环芳香手性醇, 国家自然科学基金, 2008/09/25-2011/12/31, 完成

利用镉离子比率荧光探针研究镉诱导的细胞程序化死亡过程中NO的作用机制, 国家自然科学基金, 2007/09/25-2012/12/31, 完成

特色精细化学品及工艺共性技术开发一期项目, 2017/06/13-2021/06/13, 进行

生物分子检测及医学诊断用菁荧光标记染料, 辽宁省高等学校科研计划项目, 2007/01/01-2010/09/17, 完成

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