陈匡时（研究员）的个人简介
陈匡时，博士、特聘研究员，生物医学工程系特聘研究员。
教育经历
1996-2000 学士: 加州大学-圣地亚哥校区 (UC San Diego) 专业：生物医学工程
2000-2002 硕士: 加州大学-圣地亚哥校区 (UC San Diego) 专业：生物医学工程
2004-2008 博士:宾夕法尼亚大学(University of Pennsylvania) 专业：生物医学工程
主要科研工作经历
2013-至今，北京大学工学院生物医学工程系- 特聘研究员
2010-2013， 美国国家卫生研究院 (NIH)，Jennifer Lippincott-Schwartz 实验室，博士后
2010-2012，美国国家标准与技术研究院(NIST)，Anne L. Plant 实验室，博士后
2009/2010，美国宾夕法尼亚大学，Andrew Tsourkas 实验室，博士后
获得荣誉
The US. National Research Council (NRC) Research Associate Fellowship (2010-2012).
Solomon R. Pollack Award for Excellence in Graduate Bioengineering Research (Best Ph.D. Thesis)(2009)
主要论文
1. Chen, A.K., Sengupta, P., Waki, K., Van Engelenburg, S., Ochiya, T., Ablan, S.D., Freed, E.O. and Lippincott-Schwartz, J. MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production. Proc. Natl. Acad. Sci. U S A., 2014: 111(26):E2676-83.
2. Chung, K.H.,Chen, A.K., Anderton, C.R., Bhadriraju, K., Plant, A.L., Bush, B.G., Cook, R.F. and Frank F. Frictional properties of native and functionalized type I collagen thin films. Appl. Phys. Lett. 103 (14), 143703-143703-5.
3. Chen, A.K.* Delrio, F., Peterson, A.W., Chung, K.H., Bhadriraju, K, and Plant, A.L. Cell spreading and proliferation in response to the composition and mechanics of engineered fibrillar extracellular matrices. *Corresponding Author. Biotechnol Bioeng. 2013: 110: 2731-2741.
4. Chen, A.K.* and Tsourkas A. Developing Molecular-Beacon Constructs for Improved Live-Cell Analysis and Imaging of RNA. *Corresponding Author. Am. Biotech. Lab. 2010; 28 (7): 10-13. (Review).
5. Chen, A.K., Davydenko, O., Behlke, M., and Tsourkas A.* Ratiometric Bi-Molecular Beacons: Ratiometric Bimolecular Beacons for the Sensitive Detection of RNA in Single Living Cells. Nucleic Acids Res. 2010; 38 (14): e148.
6. Cheng, Z.,Chen, A.K., Lee H-Y., and Tsourkas, A.* Examination of Folate-Targeted Liposomes with Encapsulated Poly(2-Propylacrylic acid) as a pH-responsive Nanoplatform for Cytosolic Drug Delivery. Small. 2010; 6 (13): 1398-401.
7. Chen, A.K.,Behlke, M., and Tsourkas, A.* Subcellular Trafficking and Functionality of 2’-O-methyl and 2’-O-methy-phosphorothioate Molecular Beacons. Nucleic Acids Res. 2009; 37 (22): e149.
8. Chen, A.K.and Tsourkas, A.* Imaging RNA in Living Cells with Molecular Beacons: Current Perspectives and Challenges. J. Innov. Opt. Health Sc. 2009; 2 (4): 315-324. (Review)
9. Chen, A.K., Cheng, Z., Behlke, M., and Tsourkas, A.* “Assessing the Sensitivity of Commercially Available Fluorophores to the Intracellular Environment”. Anal Chem. 2008; 80 (19): 7437-44.
10. Chen, A.K., Behlke, M., and Tsourkas, A.* “Efficient Cytosolic Delivery of Molecular Beacon Conjugates and Flow Cytometric Analysis of Target RNA”. Nucleic Acids Res. 2008; 36 (12): e69.
11. Elias, D.R., Thorek, D.L.,Chen, A.K., Czupryna, J., and Tsourkas, A.* “In vivo Imaging of Cancer Biomarkers Using Activatable Molecular Probes”. Cancer Biomarkers. 2008; 4 (6): 287-305. (Review).
12. Chen, A.K., Behlke, M., and Tsourkas, A.* “Avoiding False-Positive Signals with Nuclease-Vulnerable Molecular Beacons in Single Living Cells”. Nucleic Acids Res. 2007; 35 (16): e105.
13. Chen, A.K., Latz, M.I., Sobolewski, P., and Frangos, J.A.* “Evidence for the Role of G-Proteins in Flow Stimulation of Dinoflagellate Bioluminescence.” Am J Physiol Regul Integr Comp Physiol. 2007; 292(5): R2020-7.
14. Thorek, D.L.J.,Chen, A.K., Czupryna, J., and Tsourkas, A.* “Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging.” Ann Biomed Eng. 2006; Jan;34(1):23-38 (Review).
15.Chen, A.K., Latz, M.I., and Frangos, J.A.* The Use of Dinoflagellate Bioluminescence to Characterize Cell Stimulation in Bioreactors.” Biotechnol Bioeng. 2003; 83(1): 93-103.
出版书籍
1. Chen, A.K.,Rhee, W.J., Bao G. and Tsourkas A.* （2011）Delivery of Molecular Beacons for Live-cell Imaging and Analysis of RNA， RNA Detection and Visualization, Jeffrey E. Gerst, Humana Press, pp 159-174.
2.Crayton, S.H.,Chen, A.K.,Cheng, Z.,Tsourkas, A.*(2010) Molecular Imaging InComprehensive Biomaterials, edited by Ducheyne, P., Healy, K., Hutmacher, D., Kirkpatrick, J., Elsevier Inc.
3.Thorek, D.L.J., Czupryna, J.,Chen, A.K., Tsourkas, A.* (2006) Molecular Imaging of Cancer with Superparamagnetic Iron Oxide Nanoparticles. InCancer Imaging,edited by M.A. Hayat. Elsevier Science/Academic Press.
专利
1.Andrew Tsourkas andAntony Chen. Quantitative Molecular Probes, 2007. US Application Number: 12/282.612; International Application Number: PCT/US07/064099.
2.Andrew Tsourkas andAntony Chen. Novel Molecular Beacons. 2009. US Application Number: 61/244,378; International Application Number: PCT/US10/49301
